Company overview
The people of Memorial Sloan Kettering Cancer Center (MSK) are united by a singular mission: ending cancer for life. Our specialized care teams provide personalized, compassionate, expert care to patients of all ages. Informed by basic research done at our Sloan Kettering Institute, scientists across MSK collaborate to conduct innovative translational and clinical research that is driving a revolution in our understanding of cancer as a disease and improving the ability to prevent, diagnose, and treat it. MSK is dedicated to training the next generation of scientists and clinicians, who go on to pursue our mission at MSK and around the globe.
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Job details
Exciting Opportunity at MSK: Are you a Software Engineer enthusiastic about helping solve problems in cancer biology, genomics, and their clinical applications? Join us as a Bioinformatics Software Engineer IV! In this role you will lead the software engineering team who is developing the FDA-recognized precision oncology database OncoKB.
OncoKB is an integral component of the clinical genomics platform at MSK, codifying MSK’s immense expertise on genomic biomarkers and their clinical applications. OncoKB is currently being used to annotate all patient sequencing reports at MSK as well as thousands of patients in retrospective cohorts for cancer researchers worldwide. The OncoKB software suite has been developed in-house at MSK since 2013. It includes a curation interface that supports content curation, a public website (oncokb.org) that hosts more than 1000 daily user visits worldwide, as well as a database and API that support real-time annotation of genomic variants identified in cancer patients. To better support clinical decisions and cancer research, we are looking to expand features of all OncoKB components.
The Center for Molecular Oncology’s (CMO) mission is to promote precision oncology through genomic analysis to guide the diagnosis and treatment of cancer patients. The CMO brings together clinicians and scientists throughout MSK to conduct large-scale translational research involving molecular characterization of patient tumor specimens to identify genomic features that drive clinical outcomes.
Role Overview:
• Execute and oversee the systems, programs, and computational aspects of OncoKB. This includes leading the development and implementation of new features, ensuring the platform's stability and scalability, and leading all aspects of data management and integration.
• Lead and develop a team of software engineers, providing technical guidance, mentorship, and support. This involves fostering a collaborative and productive work environment, setting clear goals and expectations, and conducting performance reviews.
• Collaborate with the OncoKB Lead Scientist and SCMT to translate scientific and clinical requirements into technical specifications. This includes participating in meetings, reviewing documentation, and providing input on the feasibility and implementation of new features.
• Lead all aspects of the deployment of OncoKB to its various outputs, including the public website (www.oncokb.org), cBioPortal for Cancer Genomics, and MSK-IMPACT clinical reports. This involves working closely with IT and other collaborators to ensure seamless integration and data transfer.
• Ensure the security and integrity of OncoKB data, implementing appropriate access controls, data backup and recovery procedures, and data validation protocols.
• Stay abreast of emerging technologies and best practices in software engineering, evaluating and adopting new tools and methodologies to enhance the functionality and performance of the OncoKB platform.
Key Qualifications:
• Master’s degree with 5 years of experience or Bachelor's degree with 7 years of proven ability in computer science, bioinformatics, or a related field, or equivalent professional experience.
• Strong leadership and management skills, with the ability to motivate and guide a team of engineers.
• Demonstrated expertise in web application development, including proficiency in HTML5, CSS, Java, and Python.
• Extensive experience with databases such as MySQL and MongoDB.
• Strong understanding of cloud deployment principles and technologies.
• Experience with software development in a team environment using Git/GitHub or other source code control systems.
• Excellent communication and collaboration skills, with the ability to effectively interact with scientists, clinicians, and other stakeholders.
Core Skills:
• Experience with Google Firebase or similar platforms.
• Knowledge of user interface design principles and best practices.
• Prior experience working on open-source projects related to bioinformatics or cancer genomics.
• Familiarity with the principles of precision oncology and cancer variant interpretation.
Additional Information:
• Schedule: 37.5 hours Monday - Friday, hybrid
• Location: 323 E. 61st Street (Maclowe)
• Reporting to: Attending Associate
Pay Range: $131,800.00-$217,500.00
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Application Process
Bioinformatics Software Engineer IV
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