laboratory-medicine

Here at Memorial Sloan-Kettering Cancer Center (MSKCC), we're taking bold steps to redefine what's possible in Laboratory Medicine. Our state-of-the-art clinical laboratories provide sophisticated technology and automated equipment that allow our teams to get to answers faster and more efficiently, with a strong emphasis on applied and translational research.

We are committed to the growth and advancement of the department, and fully support the active collaboration of scientists, clinicians and industry experts to develop next-generation laboratory methods. MSKCC is also dedicated to providing diverse educational opportunities to further develop the skills and ambitions of our medical technologists, laboratory managers, and laboratory directors.

An all-new Laboratory Medicine facility is projected to open in 2015 to further accelerate exploration and discovery across these areas of excellence and innovation:


Cell Marker

The Cell Marker laboratory specializes in flow cytometry and focuses primarily on active clinical and research programs for the liquid tumor services at MSKCC (Leukemia, Lymphoma, Cell Therapy and Hematology). MSKCC provides exposure to a broad range of hematologic disorders. Professional and technical personnel play an active role in the development of multi-parameter flow cytometric assays, correlating our vast supply of clinical data in search of new biomarkers. Our active research programs are improving methods for detecting minimal residual disease while establishing the importance of these findings in a clinical context.

Cell Therapy

The primary role of the Cell Therapy laboratory is the manufacture of hematopoietic progenitor cells and related cell and tissue components for transplantation into MSKCC patients. Additional services include the cryopreservation of cell products and participation in early-stage (Phase I & II) clinical trials. Our work takes place against a backdrop of rigorous regulatory oversight from multiple governmental and peer-review agencies (FDA, AABB, FACT) that have consistently granted MSKCC full accreditation status.

Cellular Immunology

Cellular Immunology is an expanding specialty that utilizes advanced flow cytometric techniques to monitor immune reconstitution following stem cell transplantation. As a result, our laboratory has been able to enhance its understanding of clinical immunity and define how immunity has affected minimal residual disease and the development of graft-versus-host disease. The Cell Immunology laboratory has a close working relationship with everyone involved in the technique of graft manipulation, making the staff an integral part of the entire disease management team.

Clinical Chemistry

The Clinical Chemistry Service performs over 5.5 million assays per year, with many of our high-priority assays performed using a fully-automated robotic track system. This permits our professionals to focus more on the esoteric testing performed in several of our specialized chemistry sections. Translational research efforts include biomarker discovery, circulating tumor cell analysis, exosome biochemical discovery, proteomics and mass spectroscopy.

Hematology

The Hematology laboratory plays a central role in the diagnosis and management of patients who present a broad range of pathologies. Leading clinicians and scientists enthusiastically interact with our professional and technical staff. A highlight is our active program in the digitization of blood and bone marrow imaging, which aims to define the standard for clinical hematology for the 21st century, and our comprehensive coagulation laboratory.

Laboratory Information Systems

Our Laboratory Information Systems (LIS) team consists of system specialists and trained medical technologists who manage and support the IT needs for the laboratory. Activities include instrument interfacing, system interfacing, small systems' support, satisfying regulatory requirements, data reporting, specimen collection, point of care testing and workflow control. Our current infrastructure includes the Sunquest Laboratory Computer System and Haemonetics Software Solutions' SafeTrace Tx and SafeTrace systems. Our staff works in unison with MSKCC's IT team to ensure the effective and timely delivery of data to clinicians and researchers.

Microbiology

Microbiology Services strives to provide the best patient care through interdisciplinary collaboration with Infectious Disease, Blood and Marrow Transplant and other services. The implementation of novel molecular diagnostic technologies, such as Cepheid's GeneXpert® and Idaho Technologies' Film Array®, have improved sensitivity and specificity while reducing turnaround times. The service is integral in the training of fellows in Laboratory Medicine, Infectious Disease and Molecular Pathology. We are currently active in the translational development of mass spectrometry (MALDI-TOF) and real-time PCR methods for microbe identification.

Transfusion Services

Transfusion Services is an integral part of the cancer patient's clinical care. Our professionals are deeply involved in dealing with many complicated issues, including the treatment of immune-related cytopenias, immunosuppression, graft-versus-host disease (GVHD), cytomegalovirus (CMV) infection, and changing blood types due to developing chimerism following ABO-incompatible hematopoietic transplantation. This is accomplished through the appropriate use of complex inventories of irradiated, CMV-safe and leukocyte-reduced cellular components, and matched platelet components. We provide approximately 20% of our RBC and platelet needs and almost 100% of our plasma needs for our patients through an integrated hospital-based donor program using both whole blood and apheresis collections. Transfusion services utilize therapeutic apheresis and therapeutic plasmapheresis, as well as cytopheresis procedures, which facilitate the collection of circulating hematopoietic progenitor cells that are transfused to our large population of allogeneic and autologous transplantation patients.